Season
- Season 21 2013-01-02
- Season 20 2012-01-03
- Season 19 2011-01-03
- Season 18 2010-03-01
- Season 17 2008-06-02
- Season 16 2007-09-17
- Season 15 2006-09-18
- Season 14 2005-06-06
- Season 13 2004-06-07
- Season 12 2003-06-02
- Season 11 2002-06-03
- Season 10 2002-04-30
- Season 9 2000-08-01
- Season 8 1999-07-30
- Season 7 1998-02-26
- Season 6 1997-12-05
- Season 5 1996-09-16
- Season 4 1996-03-07
- Season 3 1994-11-28
- Season 2 1993-06-25
- Season 1 1992-05-25
- Season 0 2014-02-06
Episode
- Episode 1: Jason Lee, Elton John
- Episode 2: Justin Timberlake, Sarah Silverman
- Episode 3: Steve Carell, Jamie Lee Curtis, Joan Jett
- Episode 4: Teri Hatcher, Jon Heder, Kenny Chesney
- Episode 5: Calista Flockhart, Harland Williams, Gomez
- Episode 6: Eva Longoria, Cole and Dylan Sprouse, Death Cab for Cutie
- Episode 7: Adrien Brody, Chef G. Garvin, Alan Jackson
- Episode 8: Evangeline Lilly, Magic Johnson, Diana Krall
- Episode 9: Ashton Kutcher, Jenna Fischer, Amos Lee
- Episode 10: Jessica Simpson, Bill O'Reilly, Snow Patrol
- Episode 11: Wanda Sykes, Chris Matthews, John Mayer
- Episode 12: Helen Mirren, B.J. Novak, Jet
- Episode 13: Michael Clarke Duncan, Lisa Lampanelli, Rod Stewart
- Episode 14: Bob Newhart, Kristin Chenoweth, Camp Freddy
- Episode 15: Jarod Miller, Bradley Whitford, Ray LaMontagne
- Episode 16: Tina Fey, Annika Sorenstam, Fergie
- Episode 17: Tiger Woods, Emeril Lagasse, Chingy
- Episode 18: Arnold Schwarzenegger, Heidi Klum, Le Rêve
- Episode 19: Sandra Bullock, Michael Caine, Chris Young
- Episode 20: David Gregory, Ali Larter, Edie Brickell & The New Bohemians
- Episode 21: Hugh Jackman, Tim McGraw
- Episode 22: Jennifer Love Hewitt, Tim Burton, Barry Manilow
- Episode 23: Annette Bening, Mad Scientist David Willey, Sarah McLachlan
- Episode 24: Sally Field, Bug Man Ruud Kleinpaste, Kevin Federline
- Episode 25: John Landis & The Spiridellis Brothers, JoJo
- Episode 26: Tim Allen, 8-year-old opera singer Gwyn Mackenzie, Carrie Underwood
- Episode 27: Roseanne Barr, Sharon Osbourne, Marilyn Manson
- Episode 28: Emma Thompson, Spencer Breslin, Regina Spektor
- Episode 29: Penelope Cruz, John Stamos, "Weird Al" Yankovic
- Episode 30: Russell Crowe, Rachael Ray, Kellie Pickler
- Episode 31: Hugh Laurie, America Ferrara, the Cheetah Girls
- Episode 32: Courtney Love, Brad Garrett, OK Go
- Episode 33: Ellen DeGeneres, Fred Willard, Tony Bennett
- Episode 34: Borat, Martha Stewart, Damian Rice
- Episode 35: Lindsay Lohan, Emmitt Smith, Army Of Anyone
- Episode 36: Sharon Stone, Patricia Arquette, Vince Gill
- Episode 37: Rachel Weisz, Nick Cannon, Il Divo
- Episode 38: Jaime Pressly, Adventurer Bear Grylls, Cirque du Soleil: The Beatles - LOVE
- Episode 39: Emilio Estevez, D.L. Hughley, Josh Groban
- Episode 40: Kate Winslet, Wilmer Valderrama, Buddy Guy
- Episode 41: Demi Moore, Ron Livingston, Chris Cornell
- Episode 42: Denzel Washington, Catherine O'Hara, Jerry Lee Lewis with Kid Rock
- Episode 43: Amazing Animals With Julie Scardina, Ellen Pompeo, Nelly Furtado
- Episode 44: Howie Mandel, Nelly Furtado
- Episode 45: Kristin Davis, Ralphie May
- Episode 46: Cameron Diaz, Gwyn Mackenzie, The Wreckers
- Episode 47: Lucy Liu, Bob Saget, Snoop Dogg
- Episode 48: Al Gore, Karolina Kurkova, Fantasia
- Episode 49: Morgan Freeman, Josh Duhamel, Barenaked Ladies
- Episode 50: Sen. Barack Obama, Maggie Gyllenhaal, Taylor Hicks
- Episode 51: Cate Blanchett, Larry the Cable Guy, Corinne Bailey Rae
- Episode 52: Dennis Miller, LaDainian Tomlinson, K.T. Tunstall
- Episode 53: Jack Black, Chef G. Garvin, Paulina Rubio
- Episode 54: Mel Gibson, Bil Dwyer, Ludacris
- Episode 55: Sylvester Stallone, Parminder Nagra, Seal
- Episode 56: Former President Jimmy Carter, Edward Norton, Panic! At the Disco
- Episode 57: Jamie Foxx, Brad Paisley
- Episode 58: Dakota Fanning, Aaron Eckhart, Twisted Sister
- Episode 59: Leonardo DiCaprio, Naomi Watts, The Goo Goo Dolls
- Episode 60: Tobey Maguire, spider expert Jules Sylvester, Sarah McLachlan
- Episode 61: Samuel L. Jackson, Nick Thune, Scott Weiland
- Episode 62: Robert De Niro, Jennifer Hudson
- Episode 63: Will Smith, Pamela Anderson, Richard Roeper, The Blind Boys of Alabama
- Episode 64: Matthew McConaughey, Opie and Anthony, The Killers
- Episode 65: Dustin Hoffman, Abigail Breslin, African Children's Choir
- Episode 66: George Clooney, Maria Lark, Unwritten Law
- Episode 67: Justin Timberlake, Masi Oka, Matisyahu
- Episode 68: Hilary Swank, Tom Papa, Akon
- Episode 69: Terry Bradshaw, baker Marjorie Johnson, Papa Roach
- Episode 70: Kiefer Sutherland, Betty White, Chris Daughtry
- Episode 71: Ben Affleck, Chris Leak, Jewel
- Episode 72: Sen. John Edwards, Terri Irwin, Mindy Smith
- Episode 73: Helen Mirren, Isaac Mizrahi, Los Lonely Boys
- Episode 74: Renée Zellweger, Joy Behar, Common
- Episode 75: Paula Abdul, D.L. Hughley, Tyrese feat. Lil Jon
- Episode 76: Matt Lauer, John & Margaret Ragonese, The All-American Rejects
- Episode 77: Meredith Vieira, Ryan Reynolds, Robin Thicke
- Episode 78: James Woods, Lisa Lampanelli, Five For Fighting
- Episode 79: Don Rickles, John Stamos, Rocco DeLuca & The Burden
- Episode 80: Jennifer Garner, Ty Pennington, Bow Wow
- Episode 81: Jon Cryer, Jeff Garcia, Switchfoot
- Episode 82: Sienna Miller, Phyllis Diller, Branford Marsalis Quartet
- Episode 83: Wanda Sykes, Sendhil Ramamurthy, The Bird And The Bee
- Episode 84: Rebecca Romijn, Bob Saget, Rodrigo Y Gabriela
- Episode 85: Bill Cosby, Mary Lynn Rajskub, Katharine McPhee
- Episode 86: Diane Keaton, Ivanka Trump, The Soweto Gospel Choir
- Episode 87: Forest Whitaker, America Ferrera, Daniel Powter
- Episode 88: Abigail Breslin, Amazing Animals With Julie Scardina, Christina Aguilera
- Episode 89: Cuba Gooding Jr., Miss USA Tara Conner, The Game
- Episode 90: Clint Eastwood, Jennifer Hudson, John Waite and Alison Krauss
- Episode 91: Penelope Cruz, Tyler Perry, James Hunter
- Episode 92: Hugh Grant, Himalayan Bears With Julie Scardina, Norah Jones
- Episode 93: Mark Wahlberg, Sarah Silverman, Mat Kearney
- Episode 94: Drew Barrymore, Kyle Krichbaum, Solomon Burke
- Episode 95: Nicolas Cage, D.J. Sampson & Sam Ballerini, The Fray
- Episode 96: Dennis Miller, baker Marjorie Johnson, Taylor Swift
- Episode 97: Beyoncé, Charles Barkley, Kenny Wayne Shepherd
- Episode 98: Jim Carrey, Gov. Tom Vilsack, Dustin Kensrue
- Episode 99: Teri Hatcher, Rhys Ifans, Omarion
- Episode 100: Simon Cowell, Randy Jackson & Ryan Seacrest, Tiki Barber, Silversun Pickups
- Episode 101: Bill Maher, skydiving accident survivor Michael Holmes, Rodney Atkins
- Episode 102: Jaime Pressly, Gordon Ramsay, Gomez
- Episode 103: Peter O'Toole, Christina Ricci, Hellogoodbye
- Episode 104: Animals With Joan Embery, William H. Macy, John Mellencamp
- Episode 105: Courteney Cox, Richard Roeper, Plain White Ts
- Episode 106: John Travolta, Katt Williams, Everclear
- Episode 107: Tim Allen, Hollywood's Most Talented Animals, Fergie
- Episode 108: Howie Mandel, Chris Hansen, Korn
- Episode 109: Queen Latifah, Gerard Butler, Buckcherry
- Episode 110: Mark Wahlberg, Brad Garrett, My Chemical Romance
- Episode 111: Sandra Bullock, Andy Richter, Evanescence
- Episode 112: Minnie Driver, Bailee Madison, Finger Eleven
- Episode 113: Dan Rather, bizarre food expert Andrew Zimmern, Lloyd
- Episode 114: Terry Bradshaw, Mary Lynn Rajskub, Musiq Soulchild
- Episode 115: Terrence Howard, Bruce Fine, the cast of "Jersey Boys"
- Episode 116: David Spade, Richard Engel, Hinder
- Episode 117: Roseanne Barr, Heather Mills, James Morrison
- Episode 118: Will Ferrell, Sen. Joseph Biden, Paolo Nutini
- Episode 119: Nick Nolte, bug expert Rudd Kleinpaste, Guster
- Episode 120: Quentin Tarantino, Pete Rose, Mika
- Episode 121: Jeff Foxworthy, Charlie Engle, Kevin Lin & Ray Zahab, Dierks Bentley
- Episode 122: Hilary Swank, Carlos Mencia, Gym Class Heroes
- Episode 123: Campbell Brown, Will Arnett, Dave Koz feat. Johnny Mathis
- Episode 124: Amy Poehler, Ricky Schroder, Ozomatli
- Episode 125: Kurt Russell, Shia LaBeouf, Hilary Duff
- Episode 126: Gerard Butler, Tim McGraw
- Episode 127: Jennifer Love Hewitt, Brandi Carlile
- Episode 128: Craig T. Nelson, Molly Shannon, Sick Puppies
- Episode 129: Jeremy Piven, Jenna Fischer, John Legend
- Episode 130: Anthony Hopkins, Rose McGowan, Good Charlotte
- Episode 131: Jamie Lee Curtis, Jonathan Rhys-Meyers, Patty Griffin
- Episode 132: Wanda Sykes, Jesse James, Rickie Lee Jones
- Episode 133: Julia Louis-Dreyfus, Rep. Nancy Pelosi, Relient K
- Episode 134: Rainn Wilson, Orny Adams, The Shins
- Episode 135: Luke Wilson, Alexandra Wentworth, Lily Allen
- Episode 136: Tim Russert, Eddie Izzard, Three Days Grace
- Episode 137: Tobey Maguire, Tori Spelling, Wicked
- Episode 138: Jack Black, Sanjaya, OK Go
- Episode 139: Kevin Bacon, Hayden Panettiere, Michael Phelps
- Episode 140: Zach Braff, Pat Summitt, Joss Stone
- Episode 141: Bill Maher, Sig & Edgar Hansen, Amy Winehouse
- Episode 142: Leah Remini, Adam Brody, Mavis Staples
- Episode 143: Jarod Miller, Kiefer Sutherland, Macy Gray feat. Natalie Cole
- Episode 144: Conan O'Brien, Venus Ramey, Kings of Leon
- Episode 145: Eric Bana, Oscar De La Hoya, Kaiser Chiefs
- Episode 146: Dr. Phil McGraw, Rove McManus, Patti Smith
- Episode 147: Mitt Romney, D.L. Hughley, Fall Out Boy
- Episode 148: Howie Mandel, Bryce Howard, Alan Jackson
- Episode 149: Thomas Haden Church, 102-year-old golfer Elsie McLean, Ne-Yo
- Episode 150: Mike Myers, Floyd Mayweather, The Cat Empire
- Episode 151: Matthew Fox, Larry the Cable Guy, Feist
- Episode 152: Antonio Banderas, Brady Barr, Aqualung
- Episode 153: Cameron Diaz, 6-year-old piano prodigy Ethan Bortnick, Nelly Furtado
- Episode 154: Amazing Animals With Julie Scardina, Gov. Bill Richardson, Miranda Lambert
- Episode 155: Dominic Monaghan, "American Idol" finalists Melinda Doolittle, Blake Lewis & Jordin Sparks, Taylor Hicks
- Episode 156: Orlando Bloom, Maria Lark, Gym Class Heroes
- Episode 157: Ricki Lake, baker Marjorie Johnson, Gretchen Wilson
- Episode 158: Felicity Huffman, bizarre food expert Andrew Zimmern, Dolores O'Riordan
- Episode 159: Jamie Foxx, Jimmy Fallon, Peter Bjorn And John
- Episode 160: Simon Cowell, 95-year-old college graduate Nola Ochs, Maroon 5
- Episode 161: Demi Moore, Judd Apatow, Angelique Kidjo feat. Ziggy Marley
- Episode 162: Gov. Arnold Schwarzenegger, Debra Messing, Fiction Plane
- Episode 163: Kevin Costner, "American Idol" winner Jordin Sparks, Daniel Tosh
- Episode 164: Dennis Miller, Ross "The Intern" Mathews, Dwight Yoakam
- Episode 165: Jessica Alba, Seth Rogen, Lucinda Williams
- Episode 166: George Clooney, senior-citizen band the Zimmers, Rihanna
- Episode 167: Bernie Mac, Cat Deeley, Chris Cornell
- Episode 168: Don Rickles, Josh Flitter, Dashboard Confessional
- Episode 169: Steve Carell, Kenny Smith, The Goo Goo Dolls
- Episode 170: Wanda Sykes, Mathias Sisters, John Mayer
- Episode 171: Fred Thompson, Lauren Graham, Toby Keith
- Episode 172: Terry Bradshaw, Shia LaBeouf, James Morrison
- Episode 173: Téa Leoni, Joy Behar, Bloc Party
- Episode 174: Bill Cosby, Charlie Gilpin, Aspen Nelson & Bryant Ashton, Avril Lavigne
- Episode 175: Robin Williams, Chelsea Handler, Big & Rich
- Episode 176: Michael Chiklis, Bruce Bowen, Sugarland
- Episode 177: Samuel L. Jackson, 17-year-old reptile expert Corbin Maxey, Jesse Malin
- Episode 178: John Cusack, Tavis Smiley, Lifehouse
- Episode 179: Cedric the Entertainer, Chip Foose, Kelly Clarkson
- Episode 180: John & Elizabeth Edwards, Maz Jobrani, The Red Jumpsuit Apparatus
- Episode 181: Michael Moore, Justin Long, Mandy Moore
- Episode 182: Josh Duhamel, David Willey, Jason Aldean
- Episode 183: Dr. Phil McGraw, Leslie Mann, Velvet Revolver
- Episode 184: Ethan Hawke, Carlos Mencia, Breaking Benjamin
- Episode 185: Daniel Radcliffe, Patton Oswalt, The Decemberists
- Episode 186: Adam Sandler, Nikki Blonsky, Silverchair
- Episode 187: John Travolta, Tony Dungy, The Neville Brothers
- Episode 188: Jessica Biel, Bill Engvall, T-Pain feat. Yung Joc
- Episode 190: Bill Maher, Minnie Driver
- Episode 191: Holly Hunter, Kent Couch, Ryan Adams & The Cardinals
- Episode 192: Sandra Bullock, Chris Matthews, Suzanne Vega
- Episode 193: Don Cheadle, Miley Cyrus, Puddle of Mudd
- Episode 194: Glenn Close, Sebastian Manisalco, Marilyn Manson
- Episode 195: Amazing Animals With Julie Scardina, Aaron Eckhart, Common
- Episode 196: Rob Schneider as Lindsay Lohan, Rove McManus, Sum 41
- Episode 197: Matt Damon, George Foreman, Stephen Stills
- Episode 198: Michael Moore, Orny Adams, Perry Farrell's Satellite Party
- Episode 199: Kevin James, Arctic swimmer Lewis Pugh, Katharine McPhee
- Episode 200: Jennifer Lopez, Kevin Nealon, Glen Hansard & Markéta Irglová
- Episode 201: Chris Tucker, Marc Anthony, The John Butler Trio
- Episode 202: Heidi Klum, Anderson Cooper, Brad Paisley
- Episode 203: Claire Danes, Bob Saget, Grace Potter & The Nocturnals
- Episode 204: Hank Azaria, David Hasselhoff, Sharon Osbourne & Piers Morgan, Daddy Yankee
- Episode 205: Michelle Pfeiffer, Jonah Hill, MIMS
- Episode 206: Cuba Gooding Jr., Zac Efron, John McLaughlin
- Episode 207: Seth Rogen, animal trainer Jules Sylvester, Hot Hot Heat
- Episode 208: David Duchovny, Tiki Barber, Nick Thune
- Episode 209: Rainn Wilson, Gordon Ramsay, Fuel
- Episode 210: Drew Carey, Richard Roeper, Colbie Caillat
- Episode 211: Sen. John McCain, Bill Hader, Ben Harper and the Innocent Criminals
- Episode 212: Jeff Foxworthy, Maria Lark, Mat Kearney
- Episode 213: Jonah Hill, Michael Cera, Christopher Mintz-Plasse, Jarod Miller, Wilco
- Episode 214: Seth Green, Mike Rowe, Collective Soul
- Episode 215: Dennis Miller, Capt. Ed Kiesel, Rodrigo Y Gabriela
- Episode 216: Fred Thompson, Jerome Bettis, Travis Tritt
- Episode 217: Daniel Radcliffe, Mark Cuban, Kings of Leon
- Episode 218: Show# 3431
- Episode 219: Brad Garrett, Funny Car racer Ashley Force, Cirque du Soleil
- Episode 220: Denis Leary, Robert Klein, Spoon
- Episode 221: Kelsey Grammer, Dan Fogler, The Bravery
- Episode 222: Terry Bradshaw, Vanessa Hudgens, Michael Buble
- Episode 223: Michael Douglas, Tavis Smiley, Good Charlotte
The Tonight Show with Jay Leno Season 15 Kate Winslet, Wilmer Valderrama, Buddy Guy
Jay Leno hosts some of the biggest celebrities in the world.
